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M9640846.TXT
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1996-03-04
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Document 0846
DOCN M9640846
TI Expression of the human OX40 (hOX40) antigen in normal and neoplastic
tissues.
DT 9604
AU Durkop H; Latza U; Himmelreich P; Stein H; Institute of Pathology,
Klinikum Benjamin Franklin, Free; University of Berlin, Germany.
SO Br J Haematol. 1995 Dec;91(4):927-31. Unique Identifier : AIDSLINE
MED/96136093
AB The Ber-ACT35 mAb was raised against the human T-cell lymphotrophic
virus (HTLV) 1-transformed, CD4+ HUT 102 cell line and recognizes the
human homologue of the OX40 (hOX40) antigen. The analysis of the
expression of hOX40 by immunohistochemical techniques in malignant
lymphomas, carcinomas and non-malignant tissues of different organs
shows that hOX40 expression was almost completely restricted to T
lymphocytes. Besides T cells only a small subpopulation of macrophages
in Langerhans' cell histiocytosis and a few blasts in B-cell
non-Hodgkin's lymphoma (B-NHL) revealed a faint immunostaining with the
Ber-ACT35 mAb. Furthermore, most of the hOX40+ T-cells are CD4+.
DE Carcinoma/IMMUNOLOGY Cell Line, Transformed CD4-Positive
T-Lymphocytes/IMMUNOLOGY CD8-Positive T-Lymphocytes/IMMUNOLOGY Flow
Cytometry Human HTLV-I Immunohistochemistry Lymphoma/*IMMUNOLOGY
Macrophages/IMMUNOLOGY Receptors, Tumor Necrosis Factor/*ANALYSIS
Support, Non-U.S. Gov't T-Lymphocytes/*IMMUNOLOGY Tissue Distribution
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).